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Se7en (2006-2007)
- In the shadows that cast the "Seven Deadly Sins" murders, two pivotal figures emerged: John Doe, the enigmatic killer, and the Fat Man, a detective desperate for redemption. Before the...
- Last issue: Se7en Issue #7

Scrublands (2006-)
- **Scrublands (2006)** Unveiling rising South African cartoonist John Daly comes Fantagraphics Books with the acclaimed "Scrublands" collection. Daly's offbeat, hallucinatory, and often...
- Last issue: Scrublands TPB

Scatterbrain (2006-)
- **Scatterbrain** unfolds in Devil's Hopyard, a shadowy city steeped in crime. At its heart is Detective Jack Anderfold, a disgraced hero longing to restore his faded glory. His target is...
- Last issue: Scatterbrain (2006) Issue #4

Scarlet Traces: The Great Game (2006)
- **Scarlet Traces: The Great Game** In the aftermath of a bloody decades-long war, the British occupation of Mars has reached a deadly standstill. Prime Minister Spry's oppressive rule at home...
- Last issue: Scarlet Traces: The Great Game Issue #4

Scarface: Scarred for Life (2006-2007)
- Tony Montana, the Cuban exile and Miami gangster, survives the deadly barrage of bullets from the classic 1983 film Scarface. But his survival comes with a heavy price: severe injuries and the loss...
- Last issue: Scarface: Scarred for Life Issue #5

Savage Red Sonja: Queen of the Frozen Wastes (2006)
- **Savage Red Sonja: Queen of the Frozen Wastes** (2006) Legendary Marvel creator Frank Cho teams up with seasoned comics writer Doug Murray and rising artistic talent Homs to present a thrilling...
- Last issue: Savage Red Sonja: Queen of the Frozen Wastes Issue #4

Savage Brothers (2006-)
- In the zombie apocalypse, two ruthless brothers, Dale and Otis, own a salvage yard where they've hunkered down to enjoy the chaos. Dale's a cunning con man, while Otis is the formidable...
- Last issue: Savage Brothers Issue #3

Samurai: Heaven and Earth (2006-2007)
- In the year 1704, Samurai Asukai Shiro embarks on a perilous journey across Asia and Europe in the riveting "Samurai: Heaven & Earth" graphic novel series. Driven by the relentless...
- Last issue: Samurai: Heaven and Earth (2006) Issue #5

Sambre (2006-)
- Sambre, an ongoing Polish comic book series launched in 2006 by Egmont Polska, delves into the realm of the supernatural. With an ever-rotating roster of writers and artists, each issue presents a...
- Last issue: Sambre Issue #6

Sam Noir: Samurai Detective (2006)
- **Synopsis: Sam Noir: Samurai Detective (2006)** In the dingy depths of a third-floor office, private investigator Sam Noir encounters a fateful meeting. The enigmatic woman who captivates him...
- Last issue: Sam Noir: Samurai Detective Issue #3